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Anoikis is a common programmed death for most of detached cells, but cancer cells can obtain anoikis resistance to facilitate their distant metastasis through the circulation system.Researches have indicated that enhanced autophagic flux accounts for the survival of many cancer cells under detached conditions.Targeting ATG4B, the key factor of prim
Abstract Background Acute osteomyelitis, which is uncommon in neonates, needs to be quickly diagnosed and treated to avoid devastating sequelae.Therefore, it is important to maintain a high index of suspicion and be aware of the evolving epidemiology and of the emergence of antibiotic resistant and aggressive strains requiring careful monitoring an
Changes in higher education frequently involve the need for more flexibility in course design and delivery.Flexibility is a concept that can be operationalized in many ways.One approach to conceptualizing flexibility within courses is to distinguish planning-type flexibility, which the instructor can designate before the course begins and which nee
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